<\/span> <\/p>\n
\u3000\u3000\u6f8e\u6e43\u65b0\u95fb\u8bb0\u8005 \u8d3a\u68a8\u840d<\/font><\/p>\n 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BA.2.12.1\u5177\u6709\u66f4\u5f3a\u7684\u6297\u6027\u3002\u9664\u4e86\u514d\u75ab\u9003\u9038\u80fd\u529b\u5916\uff0c\u7814\u7a76\u663e\u793aBA.2.12.1\u7684\u523a\u7a81\u86cb\u767d\u8fd8\u5177\u6709\u66f4\u5f3a\u7684\u4f20\u67d3\u6027\u3001\u5904\u7406\u80fd\u529b\u548c\u7ec6\u80de\u878d\u5408\u3002<\/p>\n \u3000\u3000\u5728BA.2.12.1\u7684\u63a8\u52a8\u4e0b\uff0c\u7f8e\u56fd\u65b0\u51a0\u75c5\u4f8b\u6b63\u5728\u731b\u589e\u3002<\/font><\/font>\u6839\u636eCDC\u7684\u5468\u62a5\uff0c\u7f8e\u56fd\u65e5\u65b0\u589e\u75c5\u4f8b\u8f83\u4e00\u5468\u524d\u4e0a\u5347\u4e8618.8%\uff0c\u6838\u9178\u9633\u6027\u68c0\u51fa\u7387\u4e0a\u5347\u4e8623.2%\uff0c\u65e5\u65b0\u589e\u5165\u9662\u4eba\u6570\u4e0a\u5347\u4e8624.2%\u3002<\/font><\/p>\n 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\u3000\u3000\u6b64\u524d\u5916\u754c\u666e\u904d\u8ba4\u4e3a\u7684\u5965\u5bc6\u514b\u620e\u6bd2\u529b\u8f83\u5f31\uff0c\u7136\u800c\u8fd1\u671f\u6765\u81ea\u6e2f\u5927\u3001\u54c8\u4f5b\u5927\u5b66\u4e24\u4e2a\u56e2\u961f\u7684\u7814\u7a76\u5747\u663e\u793a\uff0c\u5728\u672a\u63a5\u79cd\u75ab\u82d7\u7684\u60c5\u51b5\u4e0b\uff0c\u611f\u67d3\u5965\u5bc6\u514b\u620e\u6bd2\u682a\u9762\u4e34\u7740\u4e0e\u611f\u67d3\u65e9\u671f\u65b0\u51a0\u539f\u59cb\u6bd2\u682a\u76f8\u4f3c\u7684\u6b7b\u4ea1\u98ce\u9669\u3002<\/p>\n <\/span><\/span><\/p>\n \u3000\u3000\u65b0\u95fb\u5ef6\u4f38<\/font><\/p>\n \u3000\u3000BA.2.12.1\u523a\u7a81\u86cb\u767d\u4e0a\u7684L452Q\u7a81\u53d8<\/font><\/p>\n \u3000\u3000\u6839\u636e\u8fdb\u5316\u6811\u5206\u6790\uff0cBA.2.12.1\u7684\u51fa\u73b0\u65f6\u95f4\u5e94\u8be5\u662f2021\u5e74\u672b\u52302022\u5e74\u521d\uff0c\u51fa\u73b0\u5730\u70b9\u5927\u6982\u7387\u662f\u7f8e\u56fd\uff0c\u622a\u81f34\u6708\u5168\u7403\u4e0a\u4f20\u7684BA.2.12.1\u5e8f\u521797%\u6765\u81ea\u7f8e\u56fd\u3002<\/p>\n <\/span><\/p>\n \u3000\u3000\u8981\u7406\u89e3BA.2.12.1\u51fa\u73b0L452Q\u610f\u5473\u7740\u4ec0\u4e48\uff0c\u9996\u5148\u5f97\u4e86\u89e3\u523a\u7a81\u86cb\u767d\u3002\u523a\u7a81\u86cb\u767d\uff0c\u662f\u65b0\u51a0\u75c5\u6bd2\u4e0e\u4eba\u4f53\u7ec6\u80de\u53d7\u4f53\u7ed3\u5408\u5e76\u8fdb\u5165\u5bbf\u4e3b\u7ec6\u80de\u7684\u91cd\u8981\u7ed3\u6784\u3002\u7531\u4e8e\u523a\u7a81\u86cb\u767d\u4e5f\u662f\u4e2d\u548c\u6297\u4f53\u548cT\u7ec6\u80de\u9488\u5bf9\u7684\u5bf9\u8c61\uff0c\u56e0\u6b64\u523a\u7a81\u86cb\u767d\u53d7\u5230\u7684\u6b63\u5411\u9009\u62e9\u538b\u529b\u683c\u5916\u5927\uff0c\u53d8\u5f02\u9891\u7e41\u3002<\/p>\n \u3000\u3000\u523a\u7a81\u86cb\u767d\u5171\u67091273\u4e2a\u6c28\u57fa\u9178\u4f4d\u70b9\uff0c\u7531\u76f8\u5bf9\u4e2d\u95f4\u7684681\u4f4d\u70b9\u5c06\u5176\u5206\u4e3aS1\u548cS2\u4e24\u4e2a\u4e9a\u57fa\u3002S1\u4e9a\u57fa\u7531N\u7aef\u7ed3\u6784\u57df\u548c\u53d7\u4f53\u7ed3\u6784\u57df\uff08receptor-binding domain\uff0c RBD\uff09\u6784\u6210\uff0cS2\u4e9a\u57fa\u7531\u878d\u5408\u80bd\uff08FP\uff09\u3001\u5185\u90e8\u878d\u5408\u80bd\uff08IFP\uff09\u53ca\u4e24\u4e2a\u4e03\u80bd\u91cd\u590d\u533a\u7ec4\u6210\u3002<\/p>\n \u3000\u3000\u65b0\u51a0\u75c5\u6bd2\u9897\u7c92\u901a\u8fc7\u523a\u7a81\u86cb\u767d\u7684S1\u4e9a\u57faRBD\u7ed3\u6784\u57df\u4e0eACE2\u53d7\u4f53\u7ed3\u5408\u540e\u951a\u5b9a\u5728\u4eba\u4f53\u7ec6\u80de\u4e0a\u3002\u7ec6\u80de\u4e0a\u7684\u8de8\u819c\u4e1d\u6c28\u9178\u86cb\u767d\u91762\uff08transmembrane protease serine 2\uff0cTMPRSS2\uff09\u80fd\u591f\u6fc0\u6d3b\u65b0\u51a0\u75c5\u6bd2\u5165\u4fb5\u7ec6\u80de\u3002\u5728TMPRSS2\u4f5c\u7528\u4e0bS1\u4e9a\u57fa\u88ab\u5207\u5272\uff0c\u66b4\u9732\u51faS2\u4e9a\u57fa\u4e2d\u7684FP\uff0c\u542f\u52a8\u819c\u878d\u5408\u5e76\u8fdb\u4e00\u6b65\u5c06\u75c5\u6bd2\u91ca\u653e\u5230\u5bbf\u4e3b\u7ec6\u80de\u4e2d\u3002\u968f\u540e\u75c5\u6bd2ssRNA\u9644\u7740\u5728\u6838\u7cd6\u4f53\u4e0a\u8fdb\u884c\u590d\u5236\u548c\u86cb\u767d\u7684\u7ffb\u8bd1\u5e76\u8fdb\u4e00\u6b65\u7684\u52a0\u5de5\u5305\u88c5\u6210\u65b0\u7684\u75c5\u6bd2\uff0c\u5728\u91ca\u653e\u540e\u9020\u6210\u611f\u67d3\u7684\u6269\u6563\u4e0e\u5bbf\u4e3b\u7ec6\u80de\u7684\u635f\u4f24\u5e76\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7edf\u3002<\/p>\n \u3000\u3000\u8003\u8651\u5230\u53d7\u4f53\u7ed3\u6784\u57df\uff08RBD\uff0c319\u81f3537\u4e4b\u95f4\uff09\u662f\u523a\u7a81\u86cb\u767d\u4e0eACE2\u53d7\u4f53\u7ed3\u5408\u7684\u533a\u57df\uff0c\u8fd9\u90e8\u5206\u7684\u7a81\u53d8\u53ef\u80fd\u5f71\u54cd\u514d\u75ab\u9003\u9038\u80fd\u529b\u548c\u53d7\u4f53\u4eb2\u548c\u80fd\u529b\uff0c\u56e0\u6b64\u8fd9\u90e8\u5206\u7684\u7a81\u53d8\u683c\u5916\u53d7\u5230\u75c5\u6bd2\u5b66\u5bb6\u7684\u5173\u6ce8\u3002452\u4f4d\u70b9\u4fbf\u4f4d\u4e8e\u53d7\u4f53\u7ed3\u6784\u57df\uff08RBD\uff09\u3002<\/p>\n 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